2w6w

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[[Image:2w6w.png|left|200px]]
 
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{{STRUCTURE_2w6w| PDB=2w6w | SCENE= }}
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==Crystal structure of recombinant Sperm Whale Myoglobin under 1atm of Xenon==
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<StructureSection load='2w6w' size='340' side='right'caption='[[2w6w]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2w6w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W6W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XE:XENON'>XE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w6w OCA], [https://pdbe.org/2w6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w6w RCSB], [https://www.ebi.ac.uk/pdbsum/2w6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w6w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/2w6w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w6w ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Our aim is to shed light on the conservation of potential ligand docking sites that play an important role in ligand dynamics of globins by using the technique of filling with xenon atoms internal cavities, naturally present in hemoglobin and myoglobin. In particular, we present the high resolution structures of the Xe-adduct of deoxygenated wild type human hemoglobin and a quadruple mutant (L(B10)Y and H(E7)Q in alpha and beta chains). For the sake of comparison we also determined under the same experimental conditions the xenon complex of wild type sperm whale myoglobin.The analysis revealed that the number and position of Xe binding cavities is different in the alpha and beta subunits, the latter being more similar to myoglobin. Notably no proximal Xe docking site was detected in hemoglobin, at variance with myoglobin. The pattern of internal cavities accessibility and affinity for xenon suggests a different role for the dynamics of ligand migration in the two types of hemoglobin chains as compared to myoglobin. The number and position of hydrophobic cavities in hemoglobin is briefly discussed also in comparison with the data available for other members of the globin superfamily. (c) 2009 Wiley Periodicals, Inc. Biopolymers, 2009.
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===CRYSTAL STRUCTURE OF RECOMBINANT SPERM WHALE MYOGLOBIN UNDER 1ATM OF XENON===
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Pattern of cavities in globins: The case of human hemoglobin.,Savino C, Miele AE, Draghi F, Johnson KA, Sciara G, Brunori M, Vallone B Biopolymers. 2009 Apr 13. PMID:19365817<ref>PMID:19365817</ref>
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{{ABSTRACT_PUBMED_19365817}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2w6w" style="background-color:#fffaf0;"></div>
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[[2w6w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W6W OCA].
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==See Also==
==See Also==
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*[[Myoglobin|Myoglobin]]
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*[[Myoglobin 3D structures|Myoglobin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019365817</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Physeter catodon]]
[[Category: Physeter catodon]]
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[[Category: Brunori, M.]]
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[[Category: Brunori M]]
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[[Category: Draghi, F.]]
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[[Category: Draghi F]]
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[[Category: Johnson, K A.]]
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[[Category: Johnson KA]]
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[[Category: Miele, A E.]]
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[[Category: Miele AE]]
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[[Category: Renzi, F.]]
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[[Category: Renzi F]]
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[[Category: Savino, C.]]
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[[Category: Savino C]]
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[[Category: Sciara, G.]]
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[[Category: Sciara G]]
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[[Category: Vallone, B.]]
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[[Category: Vallone B]]
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[[Category: Heme]]
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[[Category: Hydrophobic cavity]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Muscle protein]]
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[[Category: Oxygen storage]]
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[[Category: Oxygen transport]]
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[[Category: Transport]]
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[[Category: Xenon docking site]]
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Current revision

Crystal structure of recombinant Sperm Whale Myoglobin under 1atm of Xenon

PDB ID 2w6w

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