1ug8

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[[Image:1ug8.png|left|200px]]
 
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{{STRUCTURE_1ug8| PDB=1ug8 | SCENE= }}
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==NMR structure of the R3H domain from Poly(A)-specific Ribonuclease==
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<StructureSection load='1ug8' size='340' side='right'caption='[[1ug8]]' scene=''>
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===NMR structure of the R3H domain from Poly(A)-specific Ribonuclease===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ug8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UG8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ug8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ug8 OCA], [https://pdbe.org/1ug8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ug8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ug8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ug8 ProSAT], [https://www.topsan.org/Proteins/RSGI/1ug8 TOPSAN]</span></td></tr>
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[[1ug8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UG8 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARN_MOUSE PARN_MOUSE] 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ug/1ug8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ug8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ribonuclease|Ribonuclease]]
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Aoki, M.]]
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[[Category: Aoki M]]
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[[Category: Arakawa, T.]]
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[[Category: Arakawa T]]
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[[Category: Carninci, P.]]
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[[Category: Carninci P]]
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[[Category: Hayami, N.]]
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[[Category: Hayami N]]
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[[Category: Hayashizaki, Y.]]
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[[Category: Hayashizaki Y]]
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[[Category: Hirota, H.]]
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[[Category: Hirota H]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kawai, J.]]
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[[Category: Kawai J]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Kobayashi, N.]]
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[[Category: Kobayashi N]]
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[[Category: Matsuda, T.]]
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[[Category: Matsuda T]]
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[[Category: Matsuo, Y.]]
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[[Category: Matsuo Y]]
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[[Category: Muto, Y.]]
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[[Category: Muto Y]]
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[[Category: Nagata, T.]]
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[[Category: Nagata T]]
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[[Category: Osanai, T.]]
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[[Category: Osanai T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Seki E]]
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[[Category: Seki, E.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Tanaka A]]
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[[Category: Tanaka, A.]]
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[[Category: Terada T]]
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[[Category: Terada, T.]]
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[[Category: Uda H]]
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[[Category: Uda, H.]]
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[[Category: Yabuki T]]
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[[Category: Yabuki, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoshida M]]
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[[Category: Yoshida, M.]]
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[[Category: Hydrolase]]
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[[Category: Parn]]
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[[Category: R3h domain]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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Current revision

NMR structure of the R3H domain from Poly(A)-specific Ribonuclease

PDB ID 1ug8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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