2wu8

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[[Image:2wu8.png|left|200px]]
 
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{{STRUCTURE_2wu8| PDB=2wu8 | SCENE= }}
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==Structural studies of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv==
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<StructureSection load='2wu8' size='340' side='right'caption='[[2wu8]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WU8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wu8 OCA], [https://pdbe.org/2wu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wu8 RCSB], [https://www.ebi.ac.uk/pdbsum/2wu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wu8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/G6PI_MYCTU G6PI_MYCTU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/2wu8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wu8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Phosphoglucose isomerase (PGI) plays a key role in both glycolysis and gluconeogenesis inside the cell, whereas outside the cell it exhibits cytokine properties. PGI is also known to act as an autocrine motility factor, a neuroleukin agent and a differentiation and maturation mediator. Here, the first crystal structure of PGI from Mycobacterium tuberculosis H37Rv (Mtb) is reported. The structure was refined at 2.25 A resolution and revealed the presence of one molecule in the asymmetric unit with two globular domains. As known previously, the active site of Mtb PGI contains conserved residues including Glu356, Glu216 and His387 (where His387 is from the neighbouring molecule). The crystal structure of Mtb PGI was observed to be rather more similar to human PGI than other nonbacterial PGIs, with only a few differences being detected in the loops, arm and hook regions of the human and Mtb PGIs, suggesting that the M. tuberculosis enzyme uses the same enzyme mechanism.
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===STRUCTURAL STUDIES OF PHOSPHOGLUCOSE ISOMERASE FROM MYCOBACTERIUM TUBERCULOSIS H37RV===
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Structural studies of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv.,Anand K, Mathur D, Anant A, Garg LC Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt, 5):490-7. Epub 2010 Apr 29. PMID:20445242<ref>PMID:20445242</ref>
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{{ABSTRACT_PUBMED_20445242}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2wu8" style="background-color:#fffaf0;"></div>
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[[2wu8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WU8 OCA].
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==See Also==
==See Also==
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*[[Phosphoglucoisomerase|Phosphoglucoisomerase]]
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*[[Phosphoglucose isomerase 3D structures|Phosphoglucose isomerase 3D structures]]
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*[[Phosphoglucose isomerase|Phosphoglucose isomerase]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:020445242</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Glucose-6-phosphate isomerase]]
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Anand, K.]]
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[[Category: Anand K]]
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[[Category: Gluconeogenesis]]
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[[Category: Glycolysis]]
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[[Category: Isomerase]]
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[[Category: Pgi]]
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Current revision

Structural studies of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv

PDB ID 2wu8

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