3eah
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:3eah.png|left|200px]] | ||
| - | + | ==Structure of inhibited human eNOS oxygenase domain== | |
| - | + | <StructureSection load='3eah' size='340' side='right'caption='[[3eah]], [[Resolution|resolution]] 2.44Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3eah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=327:(3S,5E)-3-PROPYL-3,4-DIHYDROTHIENO[2,3-F][1,4]OXAZEPIN-5(2H)-IMINE'>327</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eah OCA], [https://pdbe.org/3eah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eah RCSB], [https://www.ebi.ac.uk/pdbsum/3eah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eah ProSAT]</span></td></tr> |
| - | [[3eah]] is a 2 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref> Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eah_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eah ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Nitric Oxide Synthase|Nitric Oxide Synthase]] | + | *[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Aberg | + | [[Category: Aberg A]] |
| - | [[Category: Andersson | + | [[Category: Andersson G]] |
| - | [[Category: Andrews | + | [[Category: Andrews G]] |
| - | [[Category: Arvai | + | [[Category: Arvai AS]] |
| - | [[Category: Cheshire | + | [[Category: Cheshire DR]] |
| - | [[Category: Connolly | + | [[Category: Connolly S]] |
| - | [[Category: Crane | + | [[Category: Crane BR]] |
| - | [[Category: Garcin | + | [[Category: Garcin ED]] |
| - | [[Category: Gensmantel | + | [[Category: Gensmantel NP]] |
| - | [[Category: Getzoff | + | [[Category: Getzoff ED]] |
| - | [[Category: Hamley | + | [[Category: Hamley PJ]] |
| - | [[Category: Kroeger | + | [[Category: Kroeger MD]] |
| - | [[Category: Mallinder | + | [[Category: Mallinder PR]] |
| - | [[Category: Mete | + | [[Category: Mete A]] |
| - | [[Category: Nicholls | + | [[Category: Nicholls DJ]] |
| - | [[Category: Rosenfeld | + | [[Category: Rosenfeld RJ]] |
| - | [[Category: St-Gallay | + | [[Category: St-Gallay SA]] |
| - | [[Category: Stuehr | + | [[Category: Stuehr DJ]] |
| - | [[Category: Tainer | + | [[Category: Tainer JA]] |
| - | [[Category: Tinker | + | [[Category: Tinker AC]] |
| - | [[Category: Wallace | + | [[Category: Wallace AV]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structure of inhibited human eNOS oxygenase domain
| |||||||||||
Categories: Homo sapiens | Large Structures | Aberg A | Andersson G | Andrews G | Arvai AS | Cheshire DR | Connolly S | Crane BR | Garcin ED | Gensmantel NP | Getzoff ED | Hamley PJ | Kroeger MD | Mallinder PR | Mete A | Nicholls DJ | Rosenfeld RJ | St-Gallay SA | Stuehr DJ | Tainer JA | Tinker AC | Wallace AV
