1kfu

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[[Image:1kfu.png|left|200px]]
 
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{{STRUCTURE_1kfu| PDB=1kfu | SCENE= }}
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==Crystal Structure of Human m-Calpain Form II==
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<StructureSection load='1kfu' size='340' side='right'caption='[[1kfu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal Structure of Human m-Calpain Form II===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1kfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dkv 1dkv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KFU FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10639123}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kfu OCA], [https://pdbe.org/1kfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kfu RCSB], [https://www.ebi.ac.uk/pdbsum/1kfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kfu ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1kfu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dkv 1dkv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KFU OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/CAN2_HUMAN CAN2_HUMAN] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/1kfu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kfu ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Calpain|Calpain]]
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*[[Calpain 3D structures|Calpain 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010639123</ref><ref group="xtra">PMID:012437134</ref><references group="xtra"/>
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[[Category: Calpain-2]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bartunik, H.]]
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[[Category: Large Structures]]
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[[Category: Bode, W.]]
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[[Category: Bartunik H]]
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[[Category: Bourenkow, G.]]
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[[Category: Bode W]]
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[[Category: Braun, M.]]
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[[Category: Bourenkow G]]
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[[Category: Fernandez-Catalan, C.]]
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[[Category: Braun M]]
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[[Category: Huber, R.]]
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[[Category: Fernandez-Catalan C]]
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[[Category: Irie, A.]]
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[[Category: Huber R]]
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[[Category: Masumoto, H.]]
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[[Category: Irie A]]
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[[Category: Nakagawa, K.]]
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[[Category: Masumoto H]]
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[[Category: Sorimachi, H.]]
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[[Category: Nakagawa K]]
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[[Category: Strobl, S.]]
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[[Category: Sorimachi H]]
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[[Category: Suzuki, K.]]
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[[Category: Strobl S]]
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[[Category: Hydrolase]]
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[[Category: Suzuki K]]
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[[Category: Papain-like]]
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[[Category: Regulation]]
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[[Category: Thiol-protease]]
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Current revision

Crystal Structure of Human m-Calpain Form II

PDB ID 1kfu

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