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2uug
From Proteopedia
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| - | [[Image:2uug.png|left|200px]] | ||
| - | + | ==ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH H187D MUTANT UDG AND WILD-TYPE UGI== | |
| - | + | <StructureSection load='2uug' size='340' side='right'caption='[[2uug]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2uug]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_PBS2 Bacillus phage PBS2] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UUG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uug OCA], [https://pdbe.org/2uug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uug RCSB], [https://www.ebi.ac.uk/pdbsum/2uug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uug ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2uug]] is a 4 chain structure with sequence from [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/UNG_ECOLI UNG_ECOLI] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.[HAMAP-Rule:MF_00148] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uu/2uug_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uug ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[DNA | + | *[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]] |
| - | *[[Uracil | + | *[[Uracil glycosylase inhibitor|Uracil glycosylase inhibitor]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Bacillus phage PBS2]] | |
| - | [[Category: Bacillus phage | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: Escherichia coli | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arvai AS]] |
| - | [[Category: Arvai | + | [[Category: Mol CD]] |
| - | [[Category: Mol | + | [[Category: Putnam CD]] |
| - | [[Category: Putnam | + | [[Category: Tainer JA]] |
| - | [[Category: Tainer | + | |
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Current revision
ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH H187D MUTANT UDG AND WILD-TYPE UGI
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