1n95

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:54, 14 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1n95.png|left|200px]]
 
-
{{STRUCTURE_1n95| PDB=1n95 | SCENE= }}
+
==Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives==
-
 
+
<StructureSection load='1n95' size='340' side='right'caption='[[1n95]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
===Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1n95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N95 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_12657282}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FTH:1-[2-(4-CYANO-BENZYLAMINO)-3-(3-METHYL-3H-IMIDAZOL-4-YL)-PROPIONYL]-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE'>FTH</scene>, <scene name='pdbligand=HFP:ALPHA-HYDROXYFARNESYLPHOSPHONIC+ACID'>HFP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n95 OCA], [https://pdbe.org/1n95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n95 RCSB], [https://www.ebi.ac.uk/pdbsum/1n95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n95 ProSAT]</span></td></tr>
-
[[1n95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N95 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n9/1n95_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n95 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Farnesyltransferase|Farnesyltransferase]]
+
*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:012657282</ref><references group="xtra"/>
+
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Cohen, J.]]
+
[[Category: Cohen J]]
-
[[Category: Conner, S J.O.]]
+
[[Category: Gu WZ]]
-
[[Category: Gu, W Z.]]
+
[[Category: Gwaltney II SL]]
-
[[Category: Hasvold, L.]]
+
[[Category: Hasvold L]]
-
[[Category: II, S L.Gwaltney.]]
+
[[Category: Imade H]]
-
[[Category: Imade, H.]]
+
[[Category: Li Q]]
-
[[Category: Li, Q.]]
+
[[Category: Nelson LT]]
-
[[Category: Nelson, L T.]]
+
[[Category: O'Conner SJ]]
-
[[Category: Sullivan, G M.]]
+
[[Category: Sullivan GM]]
-
[[Category: Wang, W.]]
+
[[Category: Wang W]]
-
[[Category: Farnesyltransferase]]
+
-
[[Category: Histidine tetrahydropyridine]]
+
-
[[Category: Prenyltransferase]]
+
-
[[Category: Transferase]]
+

Current revision

Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives

PDB ID 1n95

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n95"
Personal tools