3qpp

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[[Image:3qpp.png|left|200px]]
 
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{{STRUCTURE_3qpp| PDB=3qpp | SCENE= }}
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==Structure of PDE10-inhibitor complex==
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<StructureSection load='3qpp' size='340' side='right'caption='[[3qpp]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Structure of PDE10-inhibitor complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qpp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QPP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21650160}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PFW:7-METHOXY-4-[(3S)-3-PHENYLPIPERIDIN-1-YL]-6-[2-(QUINOLIN-2-YL)ETHOXY]QUINAZOLINE'>PFW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qpp OCA], [https://pdbe.org/3qpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qpp RCSB], [https://www.ebi.ac.uk/pdbsum/3qpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qpp ProSAT]</span></td></tr>
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[[3qpp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QPP OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE10_RAT PDE10_RAT] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:10583409</ref>
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021650160</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Marr, E S.]]
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[[Category: Marr ES]]
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[[Category: Pandit, J.]]
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[[Category: Pandit J]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Phosphodiesterase inhibitor]]
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[[Category: Structure-based drug design]]
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Current revision

Structure of PDE10-inhibitor complex

PDB ID 3qpp

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