1eym

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[[Image:1eym.png|left|200px]]
 
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{{STRUCTURE_1eym| PDB=1eym | SCENE= }}
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==FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX==
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<StructureSection load='1eym' size='340' side='right'caption='[[1eym]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1eym]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EYM FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10852943}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eym OCA], [https://pdbe.org/1eym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eym RCSB], [https://www.ebi.ac.uk/pdbsum/1eym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eym ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1eym]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYM OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/1eym_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eym ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[FK506 binding protein|FK506 binding protein]]
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010852943</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Adams, S E.]]
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[[Category: Adams SE]]
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[[Category: Andrade, L J.]]
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[[Category: Andrade LJ]]
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[[Category: Clackson, T.]]
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[[Category: Clackson T]]
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[[Category: Gilman, M.]]
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[[Category: Gilman M]]
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[[Category: Hatada, M.]]
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[[Category: Hatada M]]
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[[Category: Holt, D A.]]
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[[Category: Holt DA]]
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[[Category: Keenan, T.]]
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[[Category: Keenan T]]
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[[Category: Rivera, V M.]]
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[[Category: Rivera VM]]
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[[Category: Rollins, C T.]]
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[[Category: Rollins CT]]
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[[Category: Schravendijk, M R.van.]]
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[[Category: Woolfson DN]]
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[[Category: Woolfson, D N.]]
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[[Category: Yaeger D]]
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[[Category: Yaeger, D.]]
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[[Category: Van Schravendijk MR]]
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[[Category: Isomerase]]
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[[Category: Ligand-reversible dimer]]
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[[Category: Rotamase]]
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Current revision

FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX

PDB ID 1eym

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