2e8d

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[[Image:2e8d.png|left|200px]]
 
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{{STRUCTURE_2e8d| PDB=2e8d | SCENE= }}
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==3D Structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR==
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<StructureSection load='2e8d' size='340' side='right'caption='[[2e8d]]' scene=''>
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===3D Structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2e8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E8D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17108084}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e8d OCA], [https://pdbe.org/2e8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e8d RCSB], [https://www.ebi.ac.uk/pdbsum/2e8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e8d ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2e8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E8D OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
==See Also==
==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017108084</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fujiwara, T.]]
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[[Category: Large Structures]]
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[[Category: Beta2-microglobulin]]
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[[Category: Fujiwara T]]
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[[Category: Immune system]]
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[[Category: Protein fibril]]
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Current revision

3D Structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR

PDB ID 2e8d

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