1lxc

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[[Image:1lxc.png|left|200px]]
 
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{{STRUCTURE_1lxc| PDB=1lxc | SCENE= }}
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==Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Acrylamide Inhibitor==
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<StructureSection load='1lxc' size='340' side='right'caption='[[1lxc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Acrylamide Inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lxc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LXC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12109908}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYM:3-(6-AMINOPYRIDIN-3-YL)-N-METHYL-N-[(1-METHYL-1H-INDOL-2-YL)METHYL]ACRYLAMIDE'>AYM</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lxc OCA], [https://pdbe.org/1lxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lxc RCSB], [https://www.ebi.ac.uk/pdbsum/1lxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lxc ProSAT]</span></td></tr>
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[[1lxc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LXC OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lx/1lxc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lxc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Enoyl-Acyl-Carrier Protein Reductase|Enoyl-Acyl-Carrier Protein Reductase]]
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012109908</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Berry, W E.]]
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[[Category: Large Structures]]
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[[Category: Burgess, W J.]]
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[[Category: Berry WE]]
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[[Category: Dewolf, V.]]
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[[Category: Burgess WJ]]
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[[Category: Head, M S.]]
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[[Category: Dewolf V]]
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[[Category: Heerding, D A.]]
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[[Category: Head MS]]
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[[Category: Huffman, W F.]]
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[[Category: Heerding DA]]
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[[Category: Janson, C A.]]
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[[Category: Huffman WF]]
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[[Category: Keller, P M.]]
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[[Category: Janson CA]]
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[[Category: Miller, W H.]]
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[[Category: Keller PM]]
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[[Category: Moore, T D.]]
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[[Category: Miller WH]]
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[[Category: Newlander, K A.]]
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[[Category: Moore TD]]
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[[Category: Payne, D J.]]
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[[Category: Newlander KA]]
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[[Category: Pearson, S C.]]
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[[Category: Payne DJ]]
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[[Category: Polizzi, B J.]]
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[[Category: Pearson SC]]
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[[Category: Qiu, X.]]
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[[Category: Polizzi BJ]]
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[[Category: Rittenhouse, S F.]]
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[[Category: Qiu X]]
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[[Category: Seefeld, M A.]]
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[[Category: Rittenhouse SF]]
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[[Category: Uzinskas, I N.]]
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[[Category: Seefeld MA]]
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[[Category: Yuan, C C.K.]]
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[[Category: Uzinskas IN]]
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[[Category: Enoyl reductase]]
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[[Category: Yuan CCK]]
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[[Category: Fabi]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Acrylamide Inhibitor

PDB ID 1lxc

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