2qw9

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[[Image:2qw9.png|left|200px]]
 
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{{STRUCTURE_2qw9| PDB=2qw9 | SCENE= }}
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==Crystal structure of bovine hsc70 (1-394aa)in the apo state==
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<StructureSection load='2qw9' size='340' side='right'caption='[[2qw9]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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===Crystal structure of bovine hsc70 (1-394aa)in the apo state===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qw9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QW9 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17996706}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qw9 OCA], [https://pdbe.org/2qw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qw9 RCSB], [https://www.ebi.ac.uk/pdbsum/2qw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qw9 ProSAT]</span></td></tr>
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[[2qw9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QW9 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSP7C_BOVIN HSP7C_BOVIN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qw/2qw9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qw9 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Heat Shock Proteins|Heat Shock Proteins]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017996706</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Hinck, A P.]]
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[[Category: Large Structures]]
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[[Category: Jiang, J.]]
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[[Category: Hinck AP]]
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[[Category: Lafer, E M.]]
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[[Category: Jiang J]]
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[[Category: Maes, E G.]]
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[[Category: Lafer EM]]
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[[Category: Sousa, R.]]
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[[Category: Maes EG]]
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[[Category: Taylor, A B.]]
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[[Category: Sousa R]]
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[[Category: Wang, L.]]
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[[Category: Taylor AB]]
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[[Category: Atp-binding]]
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[[Category: Wang L]]
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[[Category: Chaperone]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Stress response]]
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Current revision

Crystal structure of bovine hsc70 (1-394aa)in the apo state

PDB ID 2qw9

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