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2kgg

From Proteopedia

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[[Image:2kgg.png|left|200px]]
 
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{{STRUCTURE_2kgg| PDB=2kgg | SCENE= }}
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==Solution Structure of JARID1A C-terminal PHD finger==
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<StructureSection load='2kgg' size='340' side='right'caption='[[2kgg]]' scene=''>
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===Solution Structure of JARID1A C-terminal PHD finger===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kgg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KGG FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19430464}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgg OCA], [https://pdbe.org/2kgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kgg RCSB], [https://www.ebi.ac.uk/pdbsum/2kgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgg ProSAT]</span></td></tr>
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[[2kgg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGG OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM5A_HUMAN KDM5A_HUMAN] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).[UniProtKB:Q3UXZ9]<ref>PMID:11358960</ref> <ref>PMID:15949438</ref> <ref>PMID:17320160</ref> <ref>PMID:17320161</ref> <ref>PMID:17320163</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kgg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kgg ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Retinoblastoma-binding protein|Retinoblastoma-binding protein]]
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*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
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*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:019430464</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Patel, D J.]]
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[[Category: Large Structures]]
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[[Category: Song, J.]]
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[[Category: Patel DJ]]
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[[Category: Wang, Z.]]
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[[Category: Song J]]
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[[Category: Chromatin regulator]]
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[[Category: Wang Z]]
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[[Category: Developmental protein]]
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[[Category: Dioxygenase]]
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[[Category: Histone modification]]
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[[Category: Iron]]
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[[Category: Jarid1a]]
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[[Category: Leukemia]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Oxidoreductase]]
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[[Category: Phd finger]]
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[[Category: Phosphoprotein]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc-finger]]
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Current revision

Solution Structure of JARID1A C-terminal PHD finger

PDB ID 2kgg

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