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1bxe

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[[Image:1bxe.png|left|200px]]
 
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{{STRUCTURE_1bxe| PDB=1bxe | SCENE= }}
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==RIBOSOMAL PROTEIN L22 FROM THERMUS THERMOPHILUS==
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<StructureSection load='1bxe' size='340' side='right'caption='[[1bxe]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===RIBOSOMAL PROTEIN L22 FROM THERMUS THERMOPHILUS===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bxe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BXE FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9862810}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bxe OCA], [https://pdbe.org/1bxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bxe RCSB], [https://www.ebi.ac.uk/pdbsum/1bxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bxe ProSAT]</span></td></tr>
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[[1bxe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXE OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL22_THETH RL22_THETH] This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). The globular domain of the protein is one of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that penetrates into the center of the 70S ribosome. This extension seems to form part of the wall of the exit tunnel (By similarity). Deleting residues 82 to 84 (the equivalent deletion in E.coli renders cells resistant to erythromycin) would probably cause the tip of the hairpin to penetrate into the tunnel.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/1bxe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bxe ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Ribosomal protein L22|Ribosomal protein L22]]
*[[Ribosomal protein L22|Ribosomal protein L22]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:009862810</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Aberg, A.]]
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[[Category: Aberg A]]
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[[Category: Al-Karadaghi, S.]]
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[[Category: Al-Karadaghi S]]
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[[Category: Davydova, N.]]
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[[Category: Davydova N]]
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[[Category: Garber, M.]]
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[[Category: Garber M]]
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[[Category: Liljas, A.]]
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[[Category: Liljas A]]
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[[Category: Nevskaya, N.]]
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[[Category: Nevskaya N]]
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[[Category: Nikonov, S.]]
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[[Category: Nikonov S]]
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[[Category: Nikulin, A.]]
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[[Category: Nikulin A]]
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[[Category: Unge, J.]]
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[[Category: Unge J]]
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[[Category: Antibiotics resistance]]
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[[Category: Protein synthesis]]
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[[Category: Ribosomal protein]]
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[[Category: Rna binding]]
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[[Category: Rna binding protein]]
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Current revision

RIBOSOMAL PROTEIN L22 FROM THERMUS THERMOPHILUS

PDB ID 1bxe

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