2rcv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:54, 30 August 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2rcv.png|left|200px]]
 
-
{{STRUCTURE_2rcv| PDB=2rcv | SCENE= }}
+
==Crystal structure of the Bacillus subtilis superoxide dismutase==
 +
<StructureSection load='2rcv' size='340' side='right'caption='[[2rcv]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2rcv]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RCV FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcv OCA], [https://pdbe.org/2rcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rcv RCSB], [https://www.ebi.ac.uk/pdbsum/2rcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rcv ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SODM_BACSU SODM_BACSU] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rcv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rcv ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The sodA gene of Bacillus subtilis was expressed in Escherichia coli, purified and crystallized. The crystal structure of MnSOD was solved by molecular replacement with four dimers per asymmetric unit and refined to an R factor of 21.1% at 1.8 A resolution. The dimer structure is very similar to that of the related enzyme from B. anthracis. Larger structural differences were observed with the human MnSOD, which has one less helix in the helical domain and a longer loop between two beta-strands and also showed differences in three amino acids at the intersubunit interface in the dimer compared with the two bacterial MnSODs. These structural differences can be exploited in the design of drugs that selectively target the Bacillus enzymes.
-
===Crystal structure of the Bacillus subtilis superoxide dismutase===
+
Structure of Bacillus subtilis superoxide dismutase.,Liu P, Ewis HE, Huang YJ, Lu CD, Tai PC, Weber IT Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt, 12):1003-7. Epub 2007 Nov 21. PMID:18084079<ref>PMID:18084079</ref>
-
{{ABSTRACT_PUBMED_18084079}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 2rcv" style="background-color:#fffaf0;"></div>
-
[[2rcv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCV OCA].
+
==See Also==
==See Also==
-
*[[Superoxide Dismutase|Superoxide Dismutase]]
+
*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:018084079</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
-
[[Category: Superoxide dismutase]]
+
[[Category: Large Structures]]
-
[[Category: Ewis, H E.]]
+
[[Category: Ewis HE]]
-
[[Category: Huang, Y J]]
+
[[Category: Huang YJ]]
-
[[Category: Liu, P.]]
+
[[Category: Liu P]]
-
[[Category: Lu, C D]]
+
[[Category: Lu CD]]
-
[[Category: Tai, P C]]
+
[[Category: Tai PC]]
-
[[Category: Weber, I T]]
+
[[Category: Weber IT]]
-
[[Category: Bacillus subtili]]
+
-
[[Category: Manganese]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Phosphorylation]]
+
-
[[Category: Stress response]]
+
-
[[Category: Superoxide dismutase]]
+

Current revision

Crystal structure of the Bacillus subtilis superoxide dismutase

PDB ID 2rcv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2rcv"
Personal tools