1jqj

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[[Image:1jqj.png|left|200px]]
 
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{{STRUCTURE_1jqj| PDB=1jqj | SCENE= }}
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==Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of the beta-delta complex==
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<StructureSection load='1jqj' size='340' side='right'caption='[[1jqj]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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===Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of the beta-delta complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jqj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQJ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11525728}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqj OCA], [https://pdbe.org/1jqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqj RCSB], [https://www.ebi.ac.uk/pdbsum/1jqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqj ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1jqj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQJ OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/1jqj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jqj ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011525728</ref><references group="xtra"/>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Donnell, M O.]]
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[[Category: Large Structures]]
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[[Category: Hingorani, M.]]
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[[Category: Hingorani M]]
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[[Category: Jeruzalmi, D.]]
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[[Category: Jeruzalmi D]]
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[[Category: Kuriyan, J.]]
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[[Category: Kuriyan J]]
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[[Category: Stewart, J.]]
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[[Category: O'Donnell M]]
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[[Category: Young, M.]]
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[[Category: Stewart J]]
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[[Category: Yurieva, O.]]
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[[Category: Young M]]
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[[Category: Zhao, Y.]]
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[[Category: Yurieva O]]
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[[Category: Aaa+ atpase]]
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[[Category: Zhao Y]]
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[[Category: Clamp loader]]
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[[Category: Dna polymerase]]
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[[Category: Dna replication]]
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[[Category: Processivity clamp]]
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[[Category: Transferase]]
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Current revision

Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of the beta-delta complex

PDB ID 1jqj

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