1zzi

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[[Image:1zzi.png|left|200px]]
 
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{{STRUCTURE_1zzi| PDB=1zzi | SCENE= }}
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==Crystal Structure Analysis of the third KH domain of hnRNP K in complex with ssDNA==
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<StructureSection load='1zzi' size='340' side='right'caption='[[1zzi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Crystal Structure Analysis of the third KH domain of hnRNP K in complex with ssDNA===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zzi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZZI FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16004877}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zzi OCA], [https://pdbe.org/1zzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zzi RCSB], [https://www.ebi.ac.uk/pdbsum/1zzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zzi ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1zzi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZI OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/HNRPK_HUMAN HNRPK_HUMAN] One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.<ref>PMID:16360036</ref> <ref>PMID:20673990</ref> <ref>PMID:22825850</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/1zzi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zzi ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nucleoprotein|Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016004877</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Backe, P H.]]
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[[Category: Large Structures]]
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[[Category: Cusack, S.]]
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[[Category: Backe PH]]
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[[Category: Messias, A C.]]
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[[Category: Cusack S]]
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[[Category: Ravelli, R B.]]
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[[Category: Messias AC]]
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[[Category: Sattler, M.]]
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[[Category: Ravelli RB]]
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[[Category: Protein-ssdna complex]]
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[[Category: Sattler M]]
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[[Category: Structural protein-dna complex]]
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Current revision

Crystal Structure Analysis of the third KH domain of hnRNP K in complex with ssDNA

PDB ID 1zzi

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