1b34

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[[Image:1b34.png|left|200px]]
 
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{{STRUCTURE_1b34| PDB=1b34 | SCENE= }}
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==CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN==
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<StructureSection load='1b34' size='340' side='right'caption='[[1b34]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1b34]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B34 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b34 OCA], [https://pdbe.org/1b34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b34 RCSB], [https://www.ebi.ac.uk/pdbsum/1b34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b34 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SMD1_HUMAN SMD1_HUMAN] May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/1b34_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b34 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F, and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs (snRNAs). These proteins share a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. Crystal structures of two Sm protein complexes, D3B and D1D2, show that these proteins have a common fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta sheet, and the D1D2 and D3B dimers superpose closely in their core regions, including the dimer interfaces. The crystal structures suggest that the seven Sm proteins could form a closed ring and the snRNAs may be bound in the positively charged central hole.
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===CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN===
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Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.,Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K Cell. 1999 Feb 5;96(3):375-87. PMID:10025403<ref>PMID:10025403</ref>
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{{ABSTRACT_PUBMED_10025403}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1b34" style="background-color:#fffaf0;"></div>
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[[1b34]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B34 OCA].
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==See Also==
==See Also==
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*[[Nucleoprotein|Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010025403</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Avis, J M.]]
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[[Category: Large Structures]]
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[[Category: Fortelle, E De La.]]
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[[Category: Avis JM]]
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[[Category: Kambach, C.]]
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[[Category: De La Fortelle E]]
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[[Category: Li, J.]]
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[[Category: Kambach C]]
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[[Category: Nagai, K.]]
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[[Category: Li J]]
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[[Category: Walke, S.]]
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[[Category: Nagai K]]
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[[Category: Young, R J.]]
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[[Category: Walke S]]
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[[Category: Core snrnp domain]]
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[[Category: Young RJ]]
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[[Category: Rna binding protein]]
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[[Category: Sle]]
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[[Category: Sm]]
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[[Category: Snrnp]]
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[[Category: Spliceosome]]
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[[Category: Splicing]]
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[[Category: Systemic lupus erythematosus]]
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Current revision

CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN

PDB ID 1b34

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