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1sa0
From Proteopedia
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| - | [[Image:1sa0.png|left|200px]] | ||
| - | + | ==TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX== | |
| - | + | <StructureSection load='1sa0' size='340' side='right'caption='[[1sa0]], [[Resolution|resolution]] 3.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1sa0]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SA0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.58Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CN2:2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE'>CN2</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sa0 OCA], [https://pdbe.org/1sa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sa0 RCSB], [https://www.ebi.ac.uk/pdbsum/1sa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sa0 ProSAT]</span></td></tr> |
| - | [[1sa0]] is a 5 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/1sa0_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sa0 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Tubulin|Tubulin]] | + | *[[Stathmin-4 3D structures|Stathmin-4 3D structures]] |
| - | + | *[[Tubulin 3D Structures|Tubulin 3D Structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Curmi | + | [[Category: Curmi PA]] |
| - | [[Category: Gigant | + | [[Category: Gigant B]] |
| - | [[Category: Jourdain | + | [[Category: Jourdain I]] |
| - | [[Category: Knossow | + | [[Category: Knossow M]] |
| - | [[Category: Lachkar | + | [[Category: Lachkar S]] |
| - | [[Category: Ravelli | + | [[Category: Ravelli RB]] |
| - | [[Category: Sobel | + | [[Category: Sobel A]] |
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Current revision
TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX
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Categories: Bos taurus | Large Structures | Rattus norvegicus | Curmi PA | Gigant B | Jourdain I | Knossow M | Lachkar S | Ravelli RB | Sobel A
