1mq8

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[[Image:1mq8.png|left|200px]]
 
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{{STRUCTURE_1mq8| PDB=1mq8 | SCENE= }}
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==Crystal structure of alphaL I domain in complex with ICAM-1==
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<StructureSection load='1mq8' size='340' side='right'caption='[[1mq8]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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===Crystal structure of alphaL I domain in complex with ICAM-1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mq8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQ8 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12526797}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mq8 OCA], [https://pdbe.org/1mq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1mq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mq8 ProSAT]</span></td></tr>
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[[1mq8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ8 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ICAM1_HUMAN ICAM1_HUMAN] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.<ref>PMID:2538243</ref> <ref>PMID:1968231</ref> <ref>PMID:11173916</ref> <ref>PMID:17875742</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mq8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mq8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Integrin|Integrin]]
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*[[Integrin 3D structures|Integrin 3D structures]]
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*[[Intercellular adhesion molecule|Intercellular adhesion molecule]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:012526797</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dong, Y.]]
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[[Category: Large Structures]]
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[[Category: Joachimiak, A.]]
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[[Category: Dong Y]]
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[[Category: Jun, C D.]]
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[[Category: Joachimiak A]]
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[[Category: Liu, J H.]]
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[[Category: Jun C-D]]
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[[Category: McCormack, A.]]
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[[Category: Liu J-H]]
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[[Category: Shimaoka, M.]]
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[[Category: McCormack A]]
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[[Category: Springer, T A.]]
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[[Category: Shimaoka M]]
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[[Category: Takagi, J.]]
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[[Category: Springer TA]]
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[[Category: Wang, J H.]]
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[[Category: Takagi J]]
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[[Category: Xiao, T.]]
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[[Category: Wang J-H]]
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[[Category: Yang, Y.]]
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[[Category: Xiao T]]
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[[Category: Zhang, R.]]
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[[Category: Yang Y]]
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[[Category: Ig superfamily]]
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[[Category: Zhang R]]
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[[Category: Immune system]]
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[[Category: Metal mediated protein interface]]
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[[Category: Rossmann fold]]
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Current revision

Crystal structure of alphaL I domain in complex with ICAM-1

PDB ID 1mq8

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