This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1mq8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1mq8" [edit=sysop:move=sysop])
Current revision (08:39, 10 April 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1mq8.png|left|200px]]
 
-
{{STRUCTURE_1mq8| PDB=1mq8 | SCENE= }}
+
==Crystal structure of alphaL I domain in complex with ICAM-1==
-
 
+
<StructureSection load='1mq8' size='340' side='right'caption='[[1mq8]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-
===Crystal structure of alphaL I domain in complex with ICAM-1===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1mq8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQ8 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_12526797}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mq8 OCA], [https://pdbe.org/1mq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1mq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mq8 ProSAT]</span></td></tr>
-
[[1mq8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ8 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ICAM1_HUMAN ICAM1_HUMAN] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.<ref>PMID:2538243</ref> <ref>PMID:1968231</ref> <ref>PMID:11173916</ref> <ref>PMID:17875742</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mq8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mq8 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Integrin|Integrin]]
+
*[[Integrin 3D structures|Integrin 3D structures]]
-
 
+
*[[Intercellular adhesion molecule|Intercellular adhesion molecule]]
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:012526797</ref><references group="xtra"/>
+
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Dong, Y.]]
+
[[Category: Large Structures]]
-
[[Category: Joachimiak, A.]]
+
[[Category: Dong Y]]
-
[[Category: Jun, C D.]]
+
[[Category: Joachimiak A]]
-
[[Category: Liu, J H.]]
+
[[Category: Jun C-D]]
-
[[Category: McCormack, A.]]
+
[[Category: Liu J-H]]
-
[[Category: Shimaoka, M.]]
+
[[Category: McCormack A]]
-
[[Category: Springer, T A.]]
+
[[Category: Shimaoka M]]
-
[[Category: Takagi, J.]]
+
[[Category: Springer TA]]
-
[[Category: Wang, J H.]]
+
[[Category: Takagi J]]
-
[[Category: Xiao, T.]]
+
[[Category: Wang J-H]]
-
[[Category: Yang, Y.]]
+
[[Category: Xiao T]]
-
[[Category: Zhang, R.]]
+
[[Category: Yang Y]]
-
[[Category: Ig superfamily]]
+
[[Category: Zhang R]]
-
[[Category: Immune system]]
+
-
[[Category: Metal mediated protein interface]]
+
-
[[Category: Rossmann fold]]
+

Current revision

Crystal structure of alphaL I domain in complex with ICAM-1

PDB ID 1mq8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mq8"
Personal tools