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1nch

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[[Image:1nch.gif|left|200px]]<br /><applet load="1nch" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1nch, resolution 2.1&Aring;" />
 
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'''STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS'''<br />
 
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==Overview==
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==STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS==
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Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells.
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<StructureSection load='1nch' size='340' side='right'caption='[[1nch]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nch]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NCH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nch OCA], [https://pdbe.org/1nch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nch RCSB], [https://www.ebi.ac.uk/pdbsum/1nch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nch ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CADH2_MOUSE CADH2_MOUSE] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.<ref>PMID:11433297</ref> <ref>PMID:17988630</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/1nch_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nch ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1NCH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=YB:'>YB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCH OCA].
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*[[Cadherin 3D structures|Cadherin 3D structures]]
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== References ==
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==Reference==
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<references/>
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Structural basis of cell-cell adhesion by cadherins., Shapiro L, Fannon AM, Kwong PD, Thompson A, Lehmann MS, Grubel G, Legrand JF, Als-Nielsen J, Colman DR, Hendrickson WA, Nature. 1995 Mar 23;374(6520):327-37. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7885471 7885471]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Als-Nielsen J]]
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[[Category: Als-Nielsen, J.]]
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[[Category: Colman DR]]
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[[Category: Colman, D R.]]
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[[Category: Fannon AM]]
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[[Category: Fannon, A M.]]
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[[Category: Grubel G]]
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[[Category: Grubel, G.]]
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[[Category: Hendrickson WA]]
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[[Category: Hendrickson, W A.]]
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[[Category: Kwong PD]]
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[[Category: Kwong, P D.]]
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[[Category: Legrand J-F]]
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[[Category: Legrand, J F.]]
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[[Category: Lehmann MS]]
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[[Category: Lehmann, M S.]]
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[[Category: Shapiro L]]
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[[Category: Shapiro, L.]]
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[[Category: Thompson A]]
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[[Category: Thompson, A.]]
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[[Category: YB]]
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[[Category: cadherin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:04:36 2008''
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Current revision

STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS

PDB ID 1nch

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