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3b1b

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[[Image:3b1b.png|left|200px]]
 
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{{STRUCTURE_3b1b| PDB=3b1b | SCENE= }}
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==The unique structure of wild type carbonic anhydrase alpha-CA1 from Chlamydomonas reinhardtii==
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<StructureSection load='3b1b' size='340' side='right'caption='[[3b1b]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3b1b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B1B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b1b OCA], [https://pdbe.org/3b1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b1b RCSB], [https://www.ebi.ac.uk/pdbsum/3b1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b1b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAH1_CHLRE CAH1_CHLRE] Reversible hydration of carbon dioxide.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Chlamydomonas reinhardtii alpha-type carbonic anhydrase (Cr-alphaCA1) is a dimeric enzyme that catalyses the interconversion of carbon dioxide and carbonic acid. The precursor form of Cr-alphaCA1 undergoes post-translational cleavage and N-glycosylation. Comparison of the genomic sequences of precursor Cr-alphaCA1 and other alphaCAs shows that Cr-alphaCA1 contains a different N-terminal sequence and two insertion sequences. A 35-residue peptide in one of the insertion sequences is deleted from the precursor during maturation. The crystal structure of the mature form of Cr-alphaCA1 has been determined at 1.88 A resolution. Each subunit is cleaved into the long and short peptides, but they are linked together by a disulfide bond. The two subunits are linked by a disulfide bond. N-Glycosylations occur at three asparagine residues and the attached N-glycans protrude into solvent regions. The subunits consist of a core beta-sheet structure composed of nine beta-strands. At the centre of the beta-sheet is the catalytic site, which contains a Zn atom bound to three histidine residues. The amino-acid residues around the Zn atom are highly conserved in other monomeric and dimeric alphaCAs. The short peptide runs near the active site and forms a hydrogen bond to the zinc-coordinated residue in the long chain, suggesting an important role for the short peptide in Cr-alphaCA1 activity.
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===The unique structure of wild type carbonic anhydrase alpha-CA1 from Chlamydomonas reinhardtii===
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The unique structure of carbonic anhydrase alphaCA1 from Chlamydomonas reinhardtii.,Suzuki K, Yang SY, Shimizu S, Morishita EC, Jiang J, Zhang F, Hoque MM, Sato Y, Tsunoda M, Sekiguchi T, Takenaka A Acta Crystallogr D Biol Crystallogr. 2011 Oct;67(Pt 10):894-901. Epub 2011 Sep 8. PMID:21931221<ref>PMID:21931221</ref>
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{{ABSTRACT_PUBMED_21931221}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3b1b" style="background-color:#fffaf0;"></div>
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[[3b1b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B1B OCA].
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==See Also==
==See Also==
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*[[Carbonic anhydrase|Carbonic anhydrase]]
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*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021931221</ref><references group="xtra"/>
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__TOC__
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[[Category: Carbonate dehydratase]]
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</StructureSection>
[[Category: Chlamydomonas reinhardtii]]
[[Category: Chlamydomonas reinhardtii]]
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[[Category: Shimizu, S.]]
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[[Category: Large Structures]]
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[[Category: Takenaka, A.]]
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[[Category: Shimizu S]]
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[[Category: Carbonic anhydrase]]
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[[Category: Takenaka A]]
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[[Category: Lyase]]
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[[Category: N-glycosylation]]
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[[Category: Zinc-finger]]
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Current revision

The unique structure of wild type carbonic anhydrase alpha-CA1 from Chlamydomonas reinhardtii

PDB ID 3b1b

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