1u2z

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[[Image:1u2z.png|left|200px]]
 
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{{STRUCTURE_1u2z| PDB=1u2z | SCENE= }}
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==Crystal structure of histone K79 methyltransferase Dot1p from yeast==
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<StructureSection load='1u2z' size='340' side='right'caption='[[1u2z]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal structure of histone K79 methyltransferase Dot1p from yeast===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1u2z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U2Z FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15292170}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u2z OCA], [https://pdbe.org/1u2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u2z RCSB], [https://www.ebi.ac.uk/pdbsum/1u2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u2z ProSAT]</span></td></tr>
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[[1u2z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U2Z OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOT1_YEAST DOT1_YEAST] Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro).<ref>PMID:9755194</ref> <ref>PMID:11029058</ref> <ref>PMID:12097318</ref> <ref>PMID:12152067</ref> <ref>PMID:12574507</ref> <ref>PMID:15632126</ref> <ref>PMID:16166626</ref> <ref>PMID:15292170</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u2/1u2z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u2z ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Histone methyltransferase|Histone methyltransferase]]
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015292170</ref><references group="xtra"/>
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__TOC__
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[[Category: Histone-lysine N-methyltransferase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Cheng, X.]]
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[[Category: Cheng X]]
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[[Category: Collins, R E.]]
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[[Category: Collins RE]]
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[[Category: Horton, J R.]]
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[[Category: Horton JR]]
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[[Category: Sawada, K.]]
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[[Category: Sawada K]]
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[[Category: Yang, Z.]]
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[[Category: Yang Z]]
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[[Category: Zhang, X.]]
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[[Category: Zhang X]]
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[[Category: Histone methyltransferase]]
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[[Category: Nucleosome]]
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[[Category: Transferase]]
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Current revision

Crystal structure of histone K79 methyltransferase Dot1p from yeast

PDB ID 1u2z

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