3bt6

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[[Image:3bt6.png|left|200px]]
 
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{{STRUCTURE_3bt6| PDB=3bt6 | SCENE= }}
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==Crystal Structure of Influenza B Virus Hemagglutinin==
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<StructureSection load='3bt6' size='340' side='right'caption='[[3bt6]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bt6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Hong_Kong/8/1973) Influenza B virus (B/Hong Kong/8/1973)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BT6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bt6 OCA], [https://pdbe.org/3bt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bt6 RCSB], [https://www.ebi.ac.uk/pdbsum/3bt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bt6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEMA_INBHK HEMA_INBHK] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/3bt6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bt6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Here we report the crystal structure of hemagglutinin (HA) from influenza B/Hong Kong/8/73 (B/HK) virus determined to 2.8 A. At a sequence identity of approximately 25% to influenza A virus HAs, B/HK HA shares a similar overall structure and domain organization. More than two dozen amino acid substitutions on influenza B virus HAs have been identified to cause antigenicity alteration in site-specific mutants, monoclonal antibody escape mutants, or field isolates. Mapping these substitutions on the structure of B/HK HA reveals four major epitopes, the 120 loop, the 150 loop, the 160 loop, and the 190 helix, that are located close in space to form a large, continuous antigenic site. Moreover, a systematic comparison of known HA structures across the entire influenza virus family reveals evolutionarily conserved ionizable residues at all regions along the chain and subunit interfaces. These ionizable residues are likely the structural basis for the pH dependence and sensitivity to ionic strength of influenza HA and hemagglutinin-esterase fusion proteins.
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===Crystal Structure of Influenza B Virus Hemagglutinin===
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Crystal structure of unliganded influenza B virus hemagglutinin.,Wang Q, Cheng F, Lu M, Tian X, Ma J J Virol. 2008 Mar;82(6):3011-20. Epub 2008 Jan 9. PMID:18184701<ref>PMID:18184701</ref>
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{{ABSTRACT_PUBMED_18184701}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3bt6" style="background-color:#fffaf0;"></div>
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[[3bt6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BT6 OCA].
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==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018184701</ref><references group="xtra"/>
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__TOC__
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[[Category: Influenza b virus]]
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</StructureSection>
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[[Category: Cheng, F.]]
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[[Category: Large Structures]]
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[[Category: Lu, M.]]
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[[Category: Cheng F]]
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[[Category: Ma, J.]]
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[[Category: Lu M]]
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[[Category: Tian, X.]]
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[[Category: Ma J]]
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[[Category: Wang, Q.]]
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[[Category: Tian X]]
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[[Category: Antigenic variation]]
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[[Category: Wang Q]]
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[[Category: Envelope protein]]
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[[Category: Fusion protein]]
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[[Category: Glycoprotein]]
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[[Category: Hemagglutinin]]
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[[Category: Lipoprotein]]
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[[Category: Membrane fusion]]
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[[Category: Palmitate]]
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[[Category: Transmembrane]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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Current revision

Crystal Structure of Influenza B Virus Hemagglutinin

PDB ID 3bt6

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