1pwl

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[[Image:1pwl.png|left|200px]]
 
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{{STRUCTURE_1pwl| PDB=1pwl | SCENE= }}
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==Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat==
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<StructureSection load='1pwl' size='340' side='right'caption='[[1pwl]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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===Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PWL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15146479}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFI:2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3-PYRROLIDINE]-1,2,3,5(2H)-TETRONE'>BFI</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pwl OCA], [https://pdbe.org/1pwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pwl RCSB], [https://www.ebi.ac.uk/pdbsum/1pwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pwl ProSAT]</span></td></tr>
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[[1pwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PWL OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pw/1pwl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pwl ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aldose Reductase|Aldose Reductase]]
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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*[[Carboxypeptidase|Carboxypeptidase]]
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015146479</ref><references group="xtra"/>
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[[Category: Aldehyde reductase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Darmanin, C.]]
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[[Category: Large Structures]]
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[[Category: El-Kabbani, O.]]
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[[Category: Darmanin C]]
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[[Category: Hazemann, I.]]
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[[Category: El-Kabbani O]]
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[[Category: Joachimiak, A.]]
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[[Category: Hazemann I]]
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[[Category: Mitschler, A.]]
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[[Category: Joachimiak A]]
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[[Category: Oka, M.]]
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[[Category: Mitschler A]]
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[[Category: Podjarny, A.]]
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[[Category: Oka M]]
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[[Category: Ruiz, F.]]
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[[Category: Podjarny A]]
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[[Category: Schneider, T R.]]
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[[Category: Ruiz F]]
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[[Category: Schulze-Briese, C.]]
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[[Category: Schneider TR]]
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[[Category: Tomizaki, T.]]
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[[Category: Schulze-Briese C]]
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[[Category: Aldose reductase]]
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[[Category: Tomizaki T]]
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[[Category: Atomic resolution]]
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[[Category: Inhibitor binding]]
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[[Category: Oxidoreductase]]
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[[Category: Ternary complex]]
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Current revision

Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat

PDB ID 1pwl

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