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3gxw

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[[Image:3gxw.png|left|200px]]
 
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{{STRUCTURE_3gxw| PDB=3gxw | SCENE= }}
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==Structure of the SH2 domain of the Candida glabrata transcription elongation factor Spt6, crystal form A==
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<StructureSection load='3gxw' size='340' side='right'caption='[[3gxw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Structure of the SH2 domain of the Candida glabrata transcription elongation factor Spt6, crystal form A===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gxw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GXW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19371747}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gxw OCA], [https://pdbe.org/3gxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gxw RCSB], [https://www.ebi.ac.uk/pdbsum/3gxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gxw ProSAT]</span></td></tr>
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[[3gxw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GXW OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPT6_CANGA SPT6_CANGA] Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gx/3gxw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gxw ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Elongation factor|Elongation factor]]
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:019371747</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Candida glabrata]]
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[[Category: Cramer P]]
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[[Category: Cramer, P.]]
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[[Category: Dengl S]]
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[[Category: Dengl, S.]]
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[[Category: Mayer A]]
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[[Category: Mayer, A.]]
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[[Category: Sun M]]
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[[Category: Sun, M.]]
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[[Category: C-terminal alpha helix]]
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[[Category: N-terminal alpha helix]]
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[[Category: Nucleus]]
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[[Category: Sh2 domain]]
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[[Category: Sh2-fold]]
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[[Category: Three stranded anti-parallel beta sheet]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

Structure of the SH2 domain of the Candida glabrata transcription elongation factor Spt6, crystal form A

PDB ID 3gxw

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