3k9p

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[[Image:3k9p.png|left|200px]]
 
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{{STRUCTURE_3k9p| PDB=3k9p | SCENE= }}
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==The crystal structure of E2-25K and ubiquitin complex==
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<StructureSection load='3k9p' size='340' side='right'caption='[[3k9p]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===The crystal structure of E2-25K and ubiquitin complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3k9p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K9P FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20826778}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k9p OCA], [https://pdbe.org/3k9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k9p RCSB], [https://www.ebi.ac.uk/pdbsum/3k9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k9p ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3k9p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9P OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/UBE2K_HUMAN UBE2K_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.<ref>PMID:8702625</ref> <ref>PMID:10634809</ref> <ref>PMID:10675012</ref> <ref>PMID:16714285</ref> <ref>PMID:16868077</ref> <ref>PMID:17873885</ref> <ref>PMID:20061386</ref> <ref>PMID:19906396</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/3k9p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k9p ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Ubiquitin|Ubiquitin]]
*[[Ubiquitin|Ubiquitin]]
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*[[3D structures of ubiquitin|3D structures of ubiquitin]]
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==Reference==
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*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
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<ref group="xtra">PMID:020826778</ref><references group="xtra"/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Large Structures]]
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[[Category: Eom, S H.]]
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[[Category: Eom SH]]
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[[Category: Kang, G B.]]
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[[Category: Kang GB]]
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[[Category: Ko, S.]]
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[[Category: Ko S]]
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[[Category: Lee, W.]]
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[[Category: Lee W]]
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[[Category: Song, S M.]]
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[[Category: Song SM]]
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[[Category: Atp-binding]]
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[[Category: Complex structure]]
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[[Category: E2-25k]]
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[[Category: Isopeptide bond]]
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[[Category: Ligase]]
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[[Category: Ligase-signaling protein complex]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Ubiquitin]]
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[[Category: Ubl conjugation pathway]]
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Current revision

The crystal structure of E2-25K and ubiquitin complex

PDB ID 3k9p

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