1mk9

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[[Image:1mk9.png|left|200px]]
 
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{{STRUCTURE_1mk9| PDB=1mk9 | SCENE= }}
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==CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA==
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<StructureSection load='1mk9' size='340' side='right'caption='[[1mk9]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mk9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MK9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mk9 OCA], [https://pdbe.org/1mk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mk9 RCSB], [https://www.ebi.ac.uk/pdbsum/1mk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mk9 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mk/1mk9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mk9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The binding of cytoplasmic proteins, such as talin, to the cytoplasmic domains of integrin adhesion receptors mediates bidirectional signal transduction. Here we report the crystal structure of the principal integrin binding and activating fragment of talin, alone and in complex with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand interaction that may be a prototype for FERM domain recognition of transmembrane receptors. In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the integrin beta 3 tail, providing structural paradigms for integrin linkage to the cell interior.
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===CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA===
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Structural determinants of integrin recognition by talin.,Garcia-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC Mol Cell. 2003 Jan;11(1):49-58. PMID:12535520<ref>PMID:12535520</ref>
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{{ABSTRACT_PUBMED_12535520}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1mk9" style="background-color:#fffaf0;"></div>
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[[1mk9]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK9 OCA].
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==See Also==
==See Also==
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*[[Talin|Talin]]
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*[[Talin 3D structures|Talin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012535520</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Calderwood, D A.]]
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[[Category: Large Structures]]
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[[Category: Campbell, I D.]]
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[[Category: Calderwood DA]]
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[[Category: Critchley, D.]]
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[[Category: Campbell ID]]
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[[Category: Garcia-Alvarez, B.]]
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[[Category: Critchley D]]
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[[Category: Ginsberg, M H.]]
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[[Category: De Pereda JM]]
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[[Category: Liddington, R C.]]
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[[Category: Garcia-Alvarez B]]
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[[Category: Pereda, J M.De.]]
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[[Category: Ginsberg MH]]
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[[Category: Ulmer, T S.]]
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[[Category: Liddington RC]]
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[[Category: Cytoskeleton npxy motif]]
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[[Category: Ulmer TS]]
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[[Category: Ferm domain]]
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[[Category: Focal adhesion]]
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[[Category: Integrin binding]]
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[[Category: Ptb domain]]
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[[Category: Structural protein]]
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Current revision

CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA

PDB ID 1mk9

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