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3r5w

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[[Image:3r5w.png|left|200px]]
 
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{{STRUCTURE_3r5w| PDB=3r5w | SCENE= }}
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==Structure of Ddn, the Deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824, with co-factor F420==
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<StructureSection load='3r5w' size='340' side='right'caption='[[3r5w]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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===Structure of Ddn, the Deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824, with co-factor F420===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3r5w]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R5W FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22244759}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.786&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F42:COENZYME+F420'>F42</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r5w OCA], [https://pdbe.org/3r5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r5w RCSB], [https://www.ebi.ac.uk/pdbsum/3r5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r5w ProSAT]</span></td></tr>
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[[3r5w]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R5W OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DDN_MYCTU DDN_MYCTU] Nitroreductase involved in the bioreductive activation of the antitubercular prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It converts PA-824 into three primary metabolites; the major one is the des-nitroimidazole (des-nitro) which generated reactive nitrogen species, including nitric oxide (NO). Reactive nitrogen species play a major role in mammalian defense against mycobacterial infections.<ref>PMID:16387854</ref> <ref>PMID:19039139</ref>
==See Also==
==See Also==
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*[[Nitroreductase|Nitroreductase]]
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*[[Nitroreductase 3D structures|Nitroreductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022244759</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Barry, C E.]]
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[[Category: Barry CE]]
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[[Category: Boshoff, H I.M.]]
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[[Category: Boshoff HIM]]
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[[Category: Bursulaya, B.]]
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[[Category: Bursulaya B]]
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[[Category: Cellitti, S E.]]
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[[Category: Cellitti SE]]
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[[Category: Cherian, J.]]
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[[Category: Cherian J]]
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[[Category: Choi, I.]]
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[[Category: Choi I]]
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[[Category: Dick, T.]]
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[[Category: Dick T]]
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[[Category: Geierstanger, B H.]]
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[[Category: Geierstanger BH]]
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[[Category: Gurumurthy, M.]]
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[[Category: Gurumurthy M]]
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[[Category: Jones, D H.]]
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[[Category: Jones DH]]
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[[Category: Lee, Y S.]]
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[[Category: Lee YS]]
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[[Category: Manjunatha, U H.]]
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[[Category: Manjunatha UH]]
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[[Category: Mukherjee, T.]]
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[[Category: Mukherjee T]]
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[[Category: Nayya, A.]]
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[[Category: Nayya A]]
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[[Category: Niyomrattanakit, P.]]
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[[Category: Niyomrattanakit P]]
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[[Category: Shaffer, J.]]
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[[Category: Shaffer J]]
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[[Category: Spraggon, G.]]
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[[Category: Spraggon G]]
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[[Category: Deazaflavin-dependent nitroreductase]]
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[[Category: Duf385]]
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[[Category: F420]]
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[[Category: Nitroimidazole]]
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[[Category: Opc-67683]]
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[[Category: Oxidoreductase]]
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[[Category: Pa-824]]
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[[Category: Split barrel-like fold]]
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Current revision

Structure of Ddn, the Deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824, with co-factor F420

PDB ID 3r5w

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