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1ww6

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[[Image:1ww6.png|left|200px]]
 
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{{STRUCTURE_1ww6| PDB=1ww6 | SCENE= }}
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==Agrocybe cylindracea galectin complexed with lactose==
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<StructureSection load='1ww6' size='340' side='right'caption='[[1ww6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Agrocybe cylindracea galectin complexed with lactose===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ww6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrocybe_cylindracea Agrocybe cylindracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WW6 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16051274}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ww6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ww6 OCA], [https://pdbe.org/1ww6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ww6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ww6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ww6 ProSAT]</span></td></tr>
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[[1ww6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrocybe_cylindracea Agrocybe cylindracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WW6 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATLE_CYCAE ATLE_CYCAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells. Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose) (PubMed:16051274).<ref>PMID:12757412</ref> <ref>PMID:16051274</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/1ww6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ww6 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Galectin|Galectin]]
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*[[Galectin 3D structures|Galectin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016051274</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Agrocybe cylindracea]]
[[Category: Agrocybe cylindracea]]
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[[Category: Ban, M.]]
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[[Category: Large Structures]]
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[[Category: Demirkan, E.]]
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[[Category: Ban M]]
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[[Category: Mikami, B.]]
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[[Category: Demirkan E]]
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[[Category: Utsumi, S.]]
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[[Category: Mikami B]]
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[[Category: Yagi, F.]]
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[[Category: Utsumi S]]
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[[Category: Yoon, H J.]]
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[[Category: Yagi F]]
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[[Category: Agrocybe cylindracea galectin]]
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[[Category: Yoon HJ]]
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[[Category: Carbohydrate recognition domain]]
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[[Category: Fungal galectin]]
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[[Category: Lactose]]
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[[Category: Sugar binding protein]]
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[[Category: X-ray crystallographic analysis]]
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Current revision

Agrocybe cylindracea galectin complexed with lactose

PDB ID 1ww6

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