1l2g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:11, 21 November 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1l2g.png|left|200px]]
 
-
{{STRUCTURE_1l2g| PDB=1l2g | SCENE= }}
+
==Structure of a C-terminally truncated form of glycoprotein D from HSV-1==
 +
<StructureSection load='1l2g' size='340' side='right'caption='[[1l2g]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1l2g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2G FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;, 2 models</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2g OCA], [https://pdbe.org/1l2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2g RCSB], [https://www.ebi.ac.uk/pdbsum/1l2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2g ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GD_HHV1P GD_HHV1P] Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, PVRL1 and 3-O-sulfated heparan sulfate. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2g_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l2g ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Herpes simplex virus (HSV) infection requires binding of the viral envelope glycoprotein D (gD) to cell surface receptors. We report the X-ray structures of a soluble, truncated ectodomain of gD both alone and in complex with the ectodomain of its cellular receptor HveA. Two bound anions suggest possible binding sites for another gD receptor, a 3-O-sulfonated heparan sulfate. Unexpectedly, the structures reveal a V-like immunoglobulin (Ig) fold at the core of gD that is closely related to cellular adhesion molecules and flanked by large N- and C-terminal extensions. The receptor binding segment of gD, an N-terminal hairpin, appears conformationally flexible, suggesting that a conformational change accompanying binding might be part of the viral entry mechanism.
-
===Structure of a C-terminally truncated form of glycoprotein D from HSV-1===
+
Herpes simplex virus glycoprotein D bound to the human receptor HveA.,Carfi A, Willis SH, Whitbeck JC, Krummenacher C, Cohen GH, Eisenberg RJ, Wiley DC Mol Cell. 2001 Jul;8(1):169-79. PMID:11511370<ref>PMID:11511370</ref>
-
{{ABSTRACT_PUBMED_11511370}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1l2g" style="background-color:#fffaf0;"></div>
-
[[1l2g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2G OCA].
+
==See Also==
==See Also==
*[[Glycoproteins B and D|Glycoproteins B and D]]
*[[Glycoproteins B and D|Glycoproteins B and D]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:011511370</ref><references group="xtra"/>
+
__TOC__
-
[[Category: Human herpesvirus 1]]
+
</StructureSection>
-
[[Category: Carfi, A.]]
+
[[Category: Human alphaherpesvirus 1]]
-
[[Category: Cohen, G H.]]
+
[[Category: Large Structures]]
-
[[Category: Eisenberg, R J.]]
+
[[Category: Carfi A]]
-
[[Category: Krummenacher, C.]]
+
[[Category: Cohen GH]]
-
[[Category: Whitbeck, J C.]]
+
[[Category: Eisenberg RJ]]
-
[[Category: Wiley, D C.]]
+
[[Category: Krummenacher C]]
-
[[Category: Willis, S H.]]
+
[[Category: Whitbeck JC]]
-
[[Category: Ig fold]]
+
[[Category: Wiley DC]]
-
[[Category: Viral envelope glycoprotein]]
+
[[Category: Willis SH]]
-
[[Category: Viral protein]]
+

Current revision

Structure of a C-terminally truncated form of glycoprotein D from HSV-1

PDB ID 1l2g

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1l2g"
Personal tools