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3e7t

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[[Image:3e7t.png|left|200px]]
 
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{{STRUCTURE_3e7t| PDB=3e7t | SCENE= }}
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==Structure of murine iNOS oxygenase domain with inhibitor AR-C102222==
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<StructureSection load='3e7t' size='340' side='right'caption='[[3e7t]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Structure of murine iNOS oxygenase domain with inhibitor AR-C102222===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3e7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The January 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nitric Oxide Synthase'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_1 10.2210/rcsb_pdb/mom_2011_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E7T FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18849972}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B14:1-(6-CYANO-3-PYRIDYLCARBONYL)-5,8-DIFLUOROSPIRO[PIPERIDINE-4,2(1H)-QUINAZOLINE]-4-AMINE'>B14</scene>, <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7t OCA], [https://pdbe.org/3e7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e7t RCSB], [https://www.ebi.ac.uk/pdbsum/3e7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7t ProSAT]</span></td></tr>
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[[3e7t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The January 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nitric Oxide Synthase'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_1 10.2210/rcsb_pdb/mom_2011_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7T OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/3e7t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e7t ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018849972</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Nitric Oxide Synthase]]
[[Category: Nitric Oxide Synthase]]
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[[Category: Nitric-oxide synthase]]
 
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Aberg, A.]]
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[[Category: Aberg A]]
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[[Category: Andersson, G.]]
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[[Category: Andersson G]]
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[[Category: Andrews, G.]]
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[[Category: Andrews G]]
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[[Category: Arvai, A S.]]
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[[Category: Arvai AS]]
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[[Category: Cheshire, D R.]]
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[[Category: Cheshire DR]]
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[[Category: Connolly, S.]]
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[[Category: Connolly S]]
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[[Category: Crane, B R.]]
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[[Category: Crane BR]]
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[[Category: Garcin, E D.]]
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[[Category: Garcin ED]]
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[[Category: Gensmantel, N P.]]
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[[Category: Gensmantel NP]]
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[[Category: Getzoff, E D.]]
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[[Category: Getzoff ED]]
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[[Category: Hamley, P J.]]
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[[Category: Hamley PJ]]
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[[Category: Kroeger, M D.]]
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[[Category: Kroeger MD]]
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[[Category: Mallinder, P R.]]
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[[Category: Mallinder PR]]
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[[Category: Mete, A.]]
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[[Category: Mete A]]
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[[Category: Nicholls, D J.]]
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[[Category: Nicholls DJ]]
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[[Category: Rosenfeld, R J.]]
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[[Category: Rosenfeld RJ]]
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[[Category: St-Gallay, S A.]]
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[[Category: St-Gallay SA]]
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[[Category: Stuehr, D J.]]
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[[Category: Stuehr DJ]]
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[[Category: Tainer, J A.]]
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[[Category: Tainer JA]]
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[[Category: Tinker, A C.]]
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[[Category: Tinker AC]]
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[[Category: Wallace, A V.]]
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[[Category: Wallace AV]]
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[[Category: Fad]]
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[[Category: Fmn]]
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[[Category: Heme]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Nadp]]
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[[Category: Nitric oxide synthase]]
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[[Category: No]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase calmodulin-binding]]
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[[Category: Tetrahydrobiopterin]]
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Current revision

Structure of murine iNOS oxygenase domain with inhibitor AR-C102222

PDB ID 3e7t

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