3e7t
From Proteopedia
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| - | [[Image:3e7t.png|left|200px]] | ||
| - | + | ==Structure of murine iNOS oxygenase domain with inhibitor AR-C102222== | |
| - | + | <StructureSection load='3e7t' size='340' side='right'caption='[[3e7t]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3e7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The January 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nitric Oxide Synthase'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_1 10.2210/rcsb_pdb/mom_2011_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E7T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B14:1-(6-CYANO-3-PYRIDYLCARBONYL)-5,8-DIFLUOROSPIRO[PIPERIDINE-4,2(1H)-QUINAZOLINE]-4-AMINE'>B14</scene>, <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7t OCA], [https://pdbe.org/3e7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e7t RCSB], [https://www.ebi.ac.uk/pdbsum/3e7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7t ProSAT]</span></td></tr> |
| - | [[3e7t]] is a 2 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/3e7t_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e7t ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Nitric Oxide Synthase|Nitric Oxide Synthase]] | + | *[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Nitric Oxide Synthase]] | [[Category: Nitric Oxide Synthase]] | ||
| - | [[Category: Nitric-oxide synthase]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Aberg | + | [[Category: Aberg A]] |
| - | [[Category: Andersson | + | [[Category: Andersson G]] |
| - | [[Category: Andrews | + | [[Category: Andrews G]] |
| - | [[Category: Arvai | + | [[Category: Arvai AS]] |
| - | [[Category: Cheshire | + | [[Category: Cheshire DR]] |
| - | [[Category: Connolly | + | [[Category: Connolly S]] |
| - | [[Category: Crane | + | [[Category: Crane BR]] |
| - | [[Category: Garcin | + | [[Category: Garcin ED]] |
| - | [[Category: Gensmantel | + | [[Category: Gensmantel NP]] |
| - | [[Category: Getzoff | + | [[Category: Getzoff ED]] |
| - | [[Category: Hamley | + | [[Category: Hamley PJ]] |
| - | [[Category: Kroeger | + | [[Category: Kroeger MD]] |
| - | [[Category: Mallinder | + | [[Category: Mallinder PR]] |
| - | [[Category: Mete | + | [[Category: Mete A]] |
| - | [[Category: Nicholls | + | [[Category: Nicholls DJ]] |
| - | [[Category: Rosenfeld | + | [[Category: Rosenfeld RJ]] |
| - | [[Category: St-Gallay | + | [[Category: St-Gallay SA]] |
| - | [[Category: Stuehr | + | [[Category: Stuehr DJ]] |
| - | [[Category: Tainer | + | [[Category: Tainer JA]] |
| - | [[Category: Tinker | + | [[Category: Tinker AC]] |
| - | [[Category: Wallace | + | [[Category: Wallace AV]] |
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Current revision
Structure of murine iNOS oxygenase domain with inhibitor AR-C102222
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Categories: Large Structures | Mus musculus | Nitric Oxide Synthase | RCSB PDB Molecule of the Month | Aberg A | Andersson G | Andrews G | Arvai AS | Cheshire DR | Connolly S | Crane BR | Garcin ED | Gensmantel NP | Getzoff ED | Hamley PJ | Kroeger MD | Mallinder PR | Mete A | Nicholls DJ | Rosenfeld RJ | St-Gallay SA | Stuehr DJ | Tainer JA | Tinker AC | Wallace AV
