1udi
From Proteopedia
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| - | [[Image:1udi.png|left|200px]] | ||
| - | + | ==NUCLEOTIDE MIMICRY IN THE CRYSTAL STRUCTURE OF THE URACIL-DNA GLYCOSYLASE-URACIL GLYCOSYLASE INHIBITOR PROTEIN COMPLEX== | |
| - | + | <StructureSection load='1udi' size='340' side='right'caption='[[1udi]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1udi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_virus_PBS1 Bacillus virus PBS1] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UDI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1udi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udi OCA], [https://pdbe.org/1udi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1udi RCSB], [https://www.ebi.ac.uk/pdbsum/1udi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1udi ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1udi]] is a 2 chain structure with sequence from [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/UNG_HHV11 UNG_HHV11] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly, in terminally differentiated neurons which lack DNA repair enzymes.<ref>PMID:7552746</ref> <ref>PMID:16306042</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ud/1udi_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1udi ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[DNA | + | *[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]] |
| - | *[[Uracil | + | *[[Uracil glycosylase inhibitor|Uracil glycosylase inhibitor]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: Bacillus | + | </StructureSection> |
| - | [[Category: | + | [[Category: Bacillus virus PBS1]] |
| - | [[Category: | + | [[Category: Human alphaherpesvirus 1 strain 17]] |
| - | [[Category: Pearl | + | [[Category: Large Structures]] |
| - | [[Category: Savva | + | [[Category: Pearl LH]] |
| - | + | [[Category: Savva R]] | |
Current revision
NUCLEOTIDE MIMICRY IN THE CRYSTAL STRUCTURE OF THE URACIL-DNA GLYCOSYLASE-URACIL GLYCOSYLASE INHIBITOR PROTEIN COMPLEX
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