3m49
From Proteopedia
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| - | [[Image:3m49.png|left|200px]] | ||
| - | + | ==Crystal Structure of Transketolase Complexed with Thiamine Diphosphate from Bacillus anthracis== | |
| - | + | <StructureSection load='3m49' size='340' side='right'caption='[[3m49]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3m49]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_ames_"ancestor" Bacillus anthracis ames "ancestor"]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3k95 3k95]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M49 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG5:1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE'>PG5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |
| - | == | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[3m49]] is a 2 chain structure with sequence from [ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3hyl|3hyl]], [[3k95|3k95]]</div></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAS3470, BA_3744, GBAA3744, GBAA_3744, tkt-2, tkt2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=261594 Bacillus anthracis Ames "Ancestor"])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m49 OCA], [https://pdbe.org/3m49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m49 RCSB], [https://www.ebi.ac.uk/pdbsum/3m49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m49 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/Q81Y15_BACAN Q81Y15_BACAN]] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.[RuleBase:RU004996] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/3m49_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m49 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Transketolase|Transketolase]] | *[[Transketolase|Transketolase]] | ||
| - | [[Category: Bacillus anthracis]] | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Bacillus anthracis ames ancestor]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Transketolase]] | [[Category: Transketolase]] | ||
| - | [[Category: Anderson, W F | + | [[Category: Anderson, W F]] |
| - | [[Category: Joachimiak, A | + | [[Category: Structural genomic]] |
| - | [[Category: Kim, Y | + | [[Category: Joachimiak, A]] |
| - | [[Category: Kwon, K | + | [[Category: Kim, Y]] |
| - | [[Category: Maltseva, N | + | [[Category: Kwon, K]] |
| + | [[Category: Maltseva, N]] | ||
[[Category: Alpha-beta-alpha sandwich]] | [[Category: Alpha-beta-alpha sandwich]] | ||
| - | [[Category: Center for structural genomics of infectious disease]] | ||
[[Category: Csgid]] | [[Category: Csgid]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Current revision
Crystal Structure of Transketolase Complexed with Thiamine Diphosphate from Bacillus anthracis
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