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3uon
From Proteopedia
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| - | [[Image:3uon.png|left|200px]] | ||
| - | + | ==Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist== | |
| - | + | <StructureSection load='3uon' size='340' side='right'caption='[[3uon]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3uon]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UON FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=QNB:(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL+HYDROXY(DIPHENYL)ACETATE'>QNB</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uon OCA], [https://pdbe.org/3uon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uon RCSB], [https://www.ebi.ac.uk/pdbsum/3uon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uon ProSAT]</span></td></tr> |
| - | [[3uon]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] |
| - | *[[ | + | *[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Escherichia virus T4]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Asada | + | [[Category: Asada H]] |
| - | [[Category: Haga | + | [[Category: Haga K]] |
| - | [[Category: Haga | + | [[Category: Haga T]] |
| - | [[Category: Kobayashi | + | [[Category: Kobayashi T]] |
| - | [[Category: Kobilka | + | [[Category: Kobilka BK]] |
| - | [[Category: Kruse | + | [[Category: Kruse AC]] |
| - | [[Category: Okada | + | [[Category: Okada T]] |
| - | [[Category: Shiroishi | + | [[Category: Shiroishi M]] |
| - | [[Category: Weis | + | [[Category: Weis WI]] |
| - | [[Category: Yurugi-Kobayashi | + | [[Category: Yurugi-Kobayashi T]] |
| - | [[Category: Zhang | + | [[Category: Zhang C]] |
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Current revision
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
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Categories: Escherichia virus T4 | Homo sapiens | Large Structures | Asada H | Haga K | Haga T | Kobayashi T | Kobilka BK | Kruse AC | Okada T | Shiroishi M | Weis WI | Yurugi-Kobayashi T | Zhang C
