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1wkw

From Proteopedia

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[[Image:1wkw.png|left|200px]]
 
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{{STRUCTURE_1wkw| PDB=1wkw | SCENE= }}
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==Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide==
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<StructureSection load='1wkw' size='340' side='right'caption='[[1wkw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wkw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WKW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16271312}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTA:P1-7-METHYLGUANOSINE-P3-ADENOSINE-5,5-TRIPHOSPHATE'>GTA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wkw OCA], [https://pdbe.org/1wkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wkw RCSB], [https://www.ebi.ac.uk/pdbsum/1wkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkw ProSAT]</span></td></tr>
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[[1wkw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKW OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/1wkw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wkw ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016271312</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fujisaki, H.]]
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[[Category: Large Structures]]
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[[Category: Ishida, T.]]
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[[Category: Fujisaki H]]
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[[Category: Kitamura, K.]]
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[[Category: Ishida T]]
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[[Category: Matsushita, Y.]]
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[[Category: Kitamura K]]
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[[Category: Miura, K.]]
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[[Category: Matsushita Y]]
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[[Category: Miyagawa, H.]]
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[[Category: Miura K]]
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[[Category: Shen, X.]]
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[[Category: Miyagawa H]]
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[[Category: Tomoo, K.]]
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[[Category: Shen X]]
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[[Category: Cap-binding protein]]
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[[Category: Tomoo K]]
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[[Category: Initiation factor]]
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[[Category: Mrna-cap]]
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[[Category: Translation]]
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[[Category: Translation-protein binding complex]]
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Current revision

Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide

PDB ID 1wkw

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