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3bxj

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[[Image:3bxj.png|left|200px]]
 
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{{STRUCTURE_3bxj| PDB=3bxj | SCENE= }}
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==Crystal Structure of the C2-GAP Fragment of synGAP==
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<StructureSection load='3bxj' size='340' side='right'caption='[[3bxj]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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===Crystal Structure of the C2-GAP Fragment of synGAP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BXJ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18323856}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bxj OCA], [https://pdbe.org/3bxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bxj RCSB], [https://www.ebi.ac.uk/pdbsum/3bxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bxj ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3bxj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXJ OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/SYGP1_RAT SYGP1_RAT] Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.<ref>PMID:15312654</ref> <ref>PMID:15500970</ref> <ref>PMID:16537406</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/3bxj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bxj ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Ras GTPase activating protein|Ras GTPase activating protein]]
*[[Ras GTPase activating protein|Ras GTPase activating protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018323856</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Ahmadian, M R.]]
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[[Category: Ahmadian MR]]
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[[Category: Bonneau, F.]]
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[[Category: Bonneau F]]
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[[Category: Eberth, A.]]
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[[Category: Eberth A]]
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[[Category: Gremer, L.]]
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[[Category: Gremer L]]
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[[Category: Hothorn, M.]]
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[[Category: Hothorn M]]
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[[Category: Kaschau, N.]]
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[[Category: Kaschau N]]
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[[Category: Parret, A.]]
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[[Category: Parret A]]
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[[Category: Pena, V.]]
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[[Category: Pena V]]
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[[Category: Scheffzek, K.]]
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[[Category: Scheffzek K]]
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[[Category: Gtpase activating protein]]
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[[Category: Gtpase activation]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Sh3-binding]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of the C2-GAP Fragment of synGAP

PDB ID 3bxj

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