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3uj0
From Proteopedia
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| - | [[Image:3uj0.png|left|200px]] | ||
| - | + | ==Crystal structure of the inositol 1,4,5-trisphosphate receptor with ligand bound form.== | |
| - | + | <StructureSection load='3uj0' size='340' side='right'caption='[[3uj0]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3uj0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UJ0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uj0 OCA], [https://pdbe.org/3uj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uj0 RCSB], [https://www.ebi.ac.uk/pdbsum/3uj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uj0 ProSAT]</span></td></tr> |
| - | [[3uj0]] is a 2 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). | ||
==See Also== | ==See Also== | ||
*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]] | *[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]] | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | < | + | [[Category: Large Structures]] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Ikura | + | [[Category: Ikura M]] |
| - | [[Category: Ishiyama | + | [[Category: Ishiyama N]] |
| - | [[Category: Seo | + | [[Category: Seo MD]] |
| - | [[Category: Stathopulos | + | [[Category: Stathopulos P]] |
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Current revision
Crystal structure of the inositol 1,4,5-trisphosphate receptor with ligand bound form.
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