3edu

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[[Image:3edu.png|left|200px]]
 
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{{STRUCTURE_3edu| PDB=3edu | SCENE= }}
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==Crystal structure of the ankyrin-binding domain of human erythroid spectrin==
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<StructureSection load='3edu' size='340' side='right'caption='[[3edu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal structure of the ankyrin-binding domain of human erythroid spectrin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3edu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EDU FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19168783}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3edu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3edu OCA], [https://pdbe.org/3edu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3edu RCSB], [https://www.ebi.ac.uk/pdbsum/3edu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3edu ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3edu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDU OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/SPTB1_HUMAN SPTB1_HUMAN] Defects in SPTB are the cause of elliptocytosis type 3 (EL3) [MIM:[https://omim.org/entry/182870 182870]. EL3 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.<ref>PMID:8226774</ref> <ref>PMID:7883966</ref> <ref>PMID:8018926</ref> <ref>PMID:1975598</ref> Defects in SPTB are the cause of spherocytosis type 2 (SPH2) [MIM:[https://omim.org/entry/182870 182870]; also known as hereditary spherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized by severe hemolytic anemia. Inheritance is autosomal dominant.
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== Function ==
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[https://www.uniprot.org/uniprot/SPTB1_HUMAN SPTB1_HUMAN] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/3edu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3edu ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Spectrin|Spectrin]]
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*[[Spectrin 3D structures|Spectrin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019168783</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Morrow, J S.]]
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[[Category: Large Structures]]
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[[Category: Simonovic, I.]]
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[[Category: Morrow JS]]
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[[Category: Simonovic, M.]]
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[[Category: Simonovic I]]
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[[Category: Stabach, P.]]
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[[Category: Simonovic M]]
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[[Category: Steitz, T A.]]
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[[Category: Stabach P]]
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[[Category: Actin capping]]
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[[Category: Steitz TA]]
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[[Category: Actin-binding]]
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[[Category: Ankyrin]]
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[[Category: Ankyrin-binding domain]]
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[[Category: Cytoskeleton]]
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[[Category: Disease mutation]]
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[[Category: Elliptocytosis]]
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[[Category: Hereditary hemolytic anemia]]
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[[Category: Phosphoprotein]]
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[[Category: Spectrin]]
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[[Category: Structural protein]]
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Current revision

Crystal structure of the ankyrin-binding domain of human erythroid spectrin

PDB ID 3edu

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