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1fyx

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[[Image:1fyx.png|left|200px]]
 
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{{STRUCTURE_1fyx| PDB=1fyx | SCENE= }}
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==CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2==
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<StructureSection load='1fyx' size='340' side='right'caption='[[1fyx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fyx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYX FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11081518}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyx OCA], [https://pdbe.org/1fyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyx RCSB], [https://www.ebi.ac.uk/pdbsum/1fyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyx ProSAT]</span></td></tr>
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[[1fyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYX OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TLR2_HUMAN TLR2_HUMAN] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/1fyx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fyx ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Toll-like Receptors|Toll-like Receptors]]
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011081518</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Horng, T.]]
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[[Category: Large Structures]]
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[[Category: Manley, J L.]]
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[[Category: Horng T]]
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[[Category: Medzhitov, R.]]
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[[Category: Manley JL]]
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[[Category: Shen, B.]]
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[[Category: Medzhitov R]]
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[[Category: Tao, X.]]
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[[Category: Shen B]]
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[[Category: Tong, L.]]
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[[Category: Tao X]]
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[[Category: Xu, Y.]]
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[[Category: Tong L]]
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[[Category: Beta-alpha-beta fold]]
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[[Category: Xu Y]]
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[[Category: Signaling protein]]
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Current revision

CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2

PDB ID 1fyx

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