1nwl

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[[Image:1nwl.png|left|200px]]
 
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{{STRUCTURE_1nwl| PDB=1nwl | SCENE= }}
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==Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic==
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<StructureSection load='1nwl' size='340' side='right'caption='[[1nwl]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NWL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12733877}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=964:3-(4-{2-[2-(2-BROMO-ACETYLAMINO)-ETHYLDISULFANYL]-ETHYLCARBAMOYL}-CYCLOHEXYLCARBAMOYL)-PYRAZINE-2-CARBOXYLIC+ACID'>964</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwl OCA], [https://pdbe.org/1nwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nwl RCSB], [https://www.ebi.ac.uk/pdbsum/1nwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwl ProSAT]</span></td></tr>
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[[1nwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWL OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nwl ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012733877</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Erlanson, D A.]]
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[[Category: Erlanson DA]]
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[[Category: Hansen, S.]]
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[[Category: Hansen S]]
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[[Category: He, M M.]]
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[[Category: He MM]]
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[[Category: Kung, J.]]
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[[Category: Kung J]]
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[[Category: McDowell, R S.]]
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[[Category: McDowell RS]]
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[[Category: Randal, M.]]
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[[Category: Randal M]]
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[[Category: Simmons, R L.]]
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[[Category: Simmons RL]]
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[[Category: Waight, A.]]
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[[Category: Waight A]]
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[[Category: Hydrolase]]
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[[Category: Protein-small molecule inhibitor complex]]
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Current revision

Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic

PDB ID 1nwl

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