4drv
From Proteopedia
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| - | [[Image:4drv.png|left|200px]] | ||
| - | + | ==Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen== | |
| - | + | <StructureSection load='4drv' size='340' side='right'caption='[[4drv]], [[Resolution|resolution]] 1.56Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4drv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rotavirus_sp. Rotavirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4drv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drv OCA], [https://pdbe.org/4drv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4drv RCSB], [https://www.ebi.ac.uk/pdbsum/4drv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4drv ProSAT]</span></td></tr> |
| - | [[4drv]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q86169_9REOV Q86169_9REOV] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880] | ||
==See Also== | ==See Also== | ||
| - | *[[Virus coat | + | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: Rotavirus sp | + | [[Category: Rotavirus sp]] |
| - | [[Category: Cortes-Penfield | + | [[Category: Cortes-Penfield NW]] |
| - | [[Category: Crawford | + | [[Category: Crawford SE]] |
| - | [[Category: Czako | + | [[Category: Czako R]] |
| - | [[Category: Estes | + | [[Category: Estes MK]] |
| - | [[Category: Hu | + | [[Category: Hu L]] |
| - | [[Category: Pendu | + | [[Category: Le Pendu J]] |
| - | [[Category: Prasad | + | [[Category: Prasad BVV]] |
| - | [[Category: Smith | + | [[Category: Smith DF]] |
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Current revision
Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen
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Categories: Large Structures | Rotavirus sp | Cortes-Penfield NW | Crawford SE | Czako R | Estes MK | Hu L | Le Pendu J | Prasad BVV | Smith DF
