1smc

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[[Image:1smc.png|left|200px]]
 
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{{STRUCTURE_1smc| PDB=1smc | SCENE= }}
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==Mycobacterium tuberculosis dUTPase complexed with dUTP in the absence of metal ion.==
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<StructureSection load='1smc' size='340' side='right'caption='[[1smc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Mycobacterium tuberculosis dUTPase complexed with dUTP in the absence of metal ion.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1smc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SMC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15276840}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUT:DEOXYURIDINE-5-TRIPHOSPHATE'>DUT</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1smc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1smc OCA], [https://pdbe.org/1smc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1smc RCSB], [https://www.ebi.ac.uk/pdbsum/1smc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1smc ProSAT]</span></td></tr>
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[[1smc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMC OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sm/1smc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1smc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
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*[[DUTPase 3D structures|DUTPase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015276840</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: DUTP diphosphatase]]
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[[Category: Cascio D]]
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[[Category: Cascio, D.]]
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[[Category: Chan S]]
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[[Category: Chan, S.]]
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[[Category: Cho US]]
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[[Category: Cho, U S.]]
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[[Category: Eisenberg D]]
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[[Category: Eisenberg, D.]]
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[[Category: Kim C-Y]]
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[[Category: Kim, C Y.]]
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[[Category: Kim M-Y]]
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[[Category: Kim, M Y.]]
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[[Category: Krupka H]]
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[[Category: Krupka, H.]]
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[[Category: Lekin T]]
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[[Category: Lekin, T.]]
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[[Category: Naranjo CM]]
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[[Category: Naranjo, C M.]]
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[[Category: Park MS]]
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[[Category: Park, M S.]]
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[[Category: Pashkov I]]
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[[Category: Pashkov, I.]]
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[[Category: Perry JL]]
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[[Category: Perry, J L.]]
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[[Category: Rogers YC]]
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[[Category: Rogers, Y C.]]
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[[Category: Sawaya MR]]
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[[Category: Sawaya, M R.]]
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[[Category: Segelke B]]
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[[Category: Segelke, B.]]
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[[Category: So M]]
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[[Category: So, M.]]
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[[Category: Terwilliger TC]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Waldo GS]]
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[[Category: Terwilliger, T C.]]
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[[Category: Yeates TO]]
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[[Category: Waldo, G S.]]
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[[Category: Yeates, T O.]]
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[[Category: Hydrolase]]
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[[Category: Jelly-roll]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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Current revision

Mycobacterium tuberculosis dUTPase complexed with dUTP in the absence of metal ion.

PDB ID 1smc

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