1bai

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[[Image:1bai.png|left|200px]]
 
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{{STRUCTURE_1bai| PDB=1bai | SCENE= }}
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==Crystal structure of Rous sarcoma virus protease in complex with inhibitor==
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<StructureSection load='1bai' size='340' side='right'caption='[[1bai]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Crystal structure of Rous sarcoma virus protease in complex with inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bai]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BAI FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9521772}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Q4:N-[(2R)-2-({N~5~-[AMINO(IMINIO)METHYL]-L-ORNITHYL-L-VALYL}AMINO)-4-METHYLPENTYL]-L-PHENYLALANYL-L-ALPHA-GLUTAMYL-L-ALANYL-L-NORLEUCINAMIDE'>0Q4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bai OCA], [https://pdbe.org/1bai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bai RCSB], [https://www.ebi.ac.uk/pdbsum/1bai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bai ProSAT]</span></td></tr>
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[[1bai]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAI OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/1bai_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bai ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Virus protease|Virus protease]]
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*[[Virus protease 3D structures|Virus protease 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:009521772</ref><ref group="xtra">PMID:017352531</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Rous sarcoma virus]]
[[Category: Rous sarcoma virus]]
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[[Category: Adomat, J M.]]
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[[Category: Adomat JM]]
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[[Category: Harrison, R W.]]
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[[Category: Harrison RW]]
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[[Category: Leis, J.]]
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[[Category: Leis J]]
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[[Category: Louis, J M.]]
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[[Category: Louis JM]]
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[[Category: Ridky, T W.]]
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[[Category: Ridky TW]]
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[[Category: Weber, I T.]]
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[[Category: Weber IT]]
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[[Category: Wu, J.]]
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[[Category: Wu J]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protein-mediated interaction]]
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[[Category: Viral maturation]]
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Current revision

Crystal structure of Rous sarcoma virus protease in complex with inhibitor

PDB ID 1bai

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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