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1wlj

From Proteopedia

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[[Image:1wlj.png|left|200px]]
 
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{{STRUCTURE_1wlj| PDB=1wlj | SCENE= }}
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==human ISG20==
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<StructureSection load='1wlj' size='340' side='right'caption='[[1wlj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===human ISG20===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wlj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WLJ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15527770}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wlj OCA], [https://pdbe.org/1wlj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wlj RCSB], [https://www.ebi.ac.uk/pdbsum/1wlj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wlj ProSAT]</span></td></tr>
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[[1wlj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLJ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISG20_HUMAN ISG20_HUMAN] Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.<ref>PMID:11401564</ref> <ref>PMID:12594219</ref> <ref>PMID:16033969</ref> <ref>PMID:21036379</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/1wlj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wlj ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Potassium Channel|Potassium Channel]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015527770</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hamasaki, T.]]
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[[Category: Large Structures]]
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[[Category: Horio, T.]]
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[[Category: Hamasaki T]]
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[[Category: Inoue, T.]]
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[[Category: Horio T]]
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[[Category: Murai, M.]]
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[[Category: Inoue T]]
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[[Category: Ohgi, T.]]
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[[Category: Murai M]]
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[[Category: Tanaka, T.]]
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[[Category: Ohgi T]]
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[[Category: Exoribonuclease]]
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[[Category: Tanaka T]]
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[[Category: Hydrolase]]
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Current revision

human ISG20

PDB ID 1wlj

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