3n71

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[[Image:3n71.png|left|200px]]
 
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{{STRUCTURE_3n71| PDB=3n71 | SCENE= }}
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==Crystal structure of cardiac specific histone methyltransferase SmyD1==
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<StructureSection load='3n71' size='340' side='right'caption='[[3n71]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal structure of cardiac specific histone methyltransferase SmyD1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3n71]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N71 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20943667}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n71 OCA], [https://pdbe.org/3n71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n71 RCSB], [https://www.ebi.ac.uk/pdbsum/3n71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n71 ProSAT]</span></td></tr>
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[[3n71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N71 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SMYD1_MOUSE SMYD1_MOUSE] Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.<ref>PMID:11923873</ref> <ref>PMID:20943667</ref>
==See Also==
==See Also==
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*[[Histone methyltransferase|Histone methyltransferase]]
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020943667</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Sirinupong, N.]]
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[[Category: Sirinupong N]]
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[[Category: Yang, Z.]]
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[[Category: Yang Z]]
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[[Category: Heart development]]
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[[Category: Histone lysine methyltransferase]]
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[[Category: Mynd]]
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[[Category: Smyd1]]
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[[Category: Transcription]]
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Current revision

Crystal structure of cardiac specific histone methyltransferase SmyD1

PDB ID 3n71

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OCA

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