3sjb

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[[Image:3sjb.png|left|200px]]
 
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{{STRUCTURE_3sjb| PDB=3sjb | SCENE= }}
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==Crystal structure of S. cerevisiae Get3 in the open state in complex with Get1 cytosolic domain==
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<StructureSection load='3sjb' size='340' side='right'caption='[[3sjb]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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===Crystal structure of S. cerevisiae Get3 in the open state in complex with Get1 cytosolic domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sjb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SJB FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21719644}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sjb OCA], [https://pdbe.org/3sjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sjb RCSB], [https://www.ebi.ac.uk/pdbsum/3sjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sjb ProSAT]</span></td></tr>
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[[3sjb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SJB OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GET3_YEAST GET3_YEAST] ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.<ref>PMID:12680698</ref> <ref>PMID:16269340</ref> <ref>PMID:18724936</ref> <ref>PMID:21866104</ref> <ref>PMID:21719644</ref>
==See Also==
==See Also==
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*[[ATPase|ATPase]]
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*[[ATPase 3D structures|ATPase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021719644</ref><references group="xtra"/>
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__TOC__
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[[Category: Saccharomyces cerevisiae]]
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</StructureSection>
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[[Category: Reitz, S.]]
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[[Category: Large Structures]]
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[[Category: Sinning, I.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Wild, K.]]
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[[Category: Reitz S]]
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[[Category: Coiled-coil]]
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[[Category: Sinning I]]
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[[Category: Get pathway]]
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[[Category: Wild K]]
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[[Category: Hydrolase-transport protein complex]]
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[[Category: Receptor complex]]
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[[Category: Ta-protein biogenesis]]
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Current revision

Crystal structure of S. cerevisiae Get3 in the open state in complex with Get1 cytosolic domain

PDB ID 3sjb

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