3raw

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[[Image:3raw.png|left|200px]]
 
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{{STRUCTURE_3raw| PDB=3raw | SCENE= }}
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==Crystal Structure of human CDC-like kinase 3 isoform in complex with leucettine L41==
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<StructureSection load='3raw' size='340' side='right'caption='[[3raw]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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===Crystal Structure of human CDC-like kinase 3 isoform in complex with leucettine L41===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3raw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RAW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3RA:5-(1,3-BENZODIOXOL-5-YLMETHYL)-2-(PHENYLAMINO)-4H-IMIDAZOL-4-ONE'>3RA</scene></td></tr>
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[[3raw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAW OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3raw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3raw OCA], [https://pdbe.org/3raw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3raw RCSB], [https://www.ebi.ac.uk/pdbsum/3raw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3raw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref>
==See Also==
==See Also==
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*[[Dual specificity protein kinase|Dual specificity protein kinase]]
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*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
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[[Category: Dual-specificity kinase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bazureau, J P.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bazureau JP]]
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[[Category: Bullock, A.]]
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[[Category: Bountra C]]
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[[Category: Carreaux, F.]]
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[[Category: Bullock A]]
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[[Category: Debdab, M.]]
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[[Category: Carreaux F]]
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[[Category: Delft, F von.]]
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[[Category: Debdab M]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Fedorov, O.]]
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[[Category: Fedorov O]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos P]]
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[[Category: King, O.]]
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[[Category: King O]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: Meijer, L.]]
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[[Category: Meijer L]]
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[[Category: Muniz, J R.C.]]
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[[Category: Muniz JRC]]
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[[Category: Renault, S.]]
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[[Category: Renault S]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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[[Category: Tyrosine-protein kinase]]
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Current revision

Crystal Structure of human CDC-like kinase 3 isoform in complex with leucettine L41

PDB ID 3raw

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