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1kbk

From Proteopedia

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[[Image:1kbk.png|left|200px]]
 
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{{STRUCTURE_1kbk| PDB=1kbk | SCENE= }}
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==Mechanistic Analyses of Catalysis in Human Pancreatic Alpha-Amylase: Detailed Kinetic and Structural Studies of Mutants of Three Conserved Carboxylic Acids==
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<StructureSection load='1kbk' size='340' side='right'caption='[[1kbk]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Mechanistic Analyses of Catalysis in Human Pancreatic Alpha-Amylase: Detailed Kinetic and Structural Studies of Mutants of Three Conserved Carboxylic Acids===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1kbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KBK FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11914097}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kbk OCA], [https://pdbe.org/1kbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kbk RCSB], [https://www.ebi.ac.uk/pdbsum/1kbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kbk ProSAT]</span></td></tr>
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[[1kbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KBK OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMYP_HUMAN AMYP_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/1kbk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kbk ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Alpha-Amylase|Alpha-Amylase]]
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*[[Amylase 3D structures|Amylase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011914097</ref><references group="xtra"/>
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[[Category: Alpha-amylase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Brayer, G D.]]
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[[Category: Large Structures]]
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[[Category: Li, C.]]
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[[Category: Brayer GD]]
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[[Category: Maurus, R.]]
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[[Category: Li C]]
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[[Category: Overall, C M.]]
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[[Category: Maurus R]]
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[[Category: Rydberg, E H.]]
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[[Category: Overall CM]]
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[[Category: Withers, S G.]]
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[[Category: Rydberg EH]]
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[[Category: Amylase]]
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[[Category: Withers SG]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Catalysis]]
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[[Category: Diabetes]]
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[[Category: Enzyme]]
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[[Category: Glycosidase]]
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[[Category: Glycosylation]]
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[[Category: Human]]
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[[Category: Hydrolase]]
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[[Category: Mutagenesis]]
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[[Category: Pancreatic]]
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Current revision

Mechanistic Analyses of Catalysis in Human Pancreatic Alpha-Amylase: Detailed Kinetic and Structural Studies of Mutants of Three Conserved Carboxylic Acids

PDB ID 1kbk

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